منابع مشابه
Subthreshold oscillations and neuronal input-output relationships
The difference between resonator and integrator neurons relies upon a frequency preference for the former, while the latter monotonically increase their spiking probability with the frequency of a periodic input. In model neurons where dynamics on multiple time scales are present (hence ubiquitously in real neurons) the concept of frequency preference can naturally be broaden to take into accou...
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Assessing the role of biophysical parameter variations in neuronal activity is critical to the understanding of modulation, robustness, and homeostasis of neuronal signalling. The paper proposes that this question can be addressed through the analysis of dynamic input conductances. Those voltage-dependent curves aggregate the concomitant activity of all ion channels in distinct timescales. They...
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Neurons in vivo are continuously bombarded by synaptic input—so how can they detect particular inputs against this background of synaptic activity? We study how modulating background synaptic input can change neuronal sensitivity to a subset of synchronized inputs. We 3nd that changes in net excitation or inhibition vary both the probability of detecting synchronous input and also the probabili...
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It is now widely accepted that cancer is attributed to the accumulation of genetic alterations in cells. Thus, to understand the molecular mechanisms of cancer metastasis, it is indispensable to identify the genes whose alterations accumulate during cancer progression as well as the genes whose expression is responsible for the acquisition of metastatic potential in cancer cells. Molecular anal...
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ژورنال
عنوان ژورنال: Annals of Translational Medicine
سال: 2018
ISSN: 2305-5839,2305-5847
DOI: 10.21037/atm.2018.01.01